Molecular Toxicology of Chromatin: The Role of Poly (ADP-Ribose) in Gene Control
Abstract
This research endeavor approaches 'chromatin toxicity' in a selective manner. Environmental factors (both physical and chemical) exert a subtle long- term effect on cellular systems, that is distinguishable from the acute lethal effects of toxins or high doses of radiation. We focus our attention on the effect of 'low-dose' toxicology which affects cellular behavior and alters cellular phenotype. Present concepts define the molecular basis of cellular phenotype as a carefully and specifically orchestrated composite of gene- expressions, which contain both the determinants of cellular phenotype and life expectancies of specific cell types. Notably, chemical or radiation effects will inevitably result in cellulary phenotypic chages, the most pervasive being malignancy. The specific experimental approach commenced with the study of the nuclear polymer (ADP-ribose)N, which we predicted could lead to a more basic understanding of gene regulations (proto-oncogene and differentiation regulation being the defined field). Keywords: Antitransformation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 15, 1985
- Accession Number
- ADA167563
Entities
People
- Ernest Kun
Organizations
- University of California, San Francisco