Acute Oral Toxicity of (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1- Oxo-2-Butenyl) Quinoline (CHR5) in Male and Female Rats

Abstract

The acute oral toxicity of (E)-1,2,3,4-tetrahydro-6-methyl-1-(2- methyl-1-Oxo-2-Butenyl) Quinoline (CHR5) was determined in Sprague-Dawley rats by using the oral gavage single-dose method. The LD50 was 2.73 g/kg for male rats and 2.22 g/kg for female rats. CHR5 produces a syndrome of general malaise and appears to target the upper gastrointestinal tract and the central nervous system. The predominate GFI sign was increased salivation. CNS signs included loss of equilibrium, twitching, tremors, hypotonia, and depression of the grasping, pinch, pull, and righting reflexes.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1986
Accession Number
ADA167754

Entities

People

  • Carolyn M. Lewis
  • Don W. Korte Jr.
  • Earl W. Morgan
  • Gerald F. S. Hiatt

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Central Nervous System
  • Chemical Compounds
  • Digestive System
  • Gastrointestinal Tract
  • Insect Repellents
  • Lethal Dosage
  • Medical Personnel
  • Military Research
  • Nervous System
  • Plastic Explosives
  • Statistical Analysis
  • Toxicology
  • Two Dimensional
  • Upper Gastrointestinal Tract

Readers

  • Toxicology/Environmental Toxicology