Pardaxin's Action in Shark,

Abstract

Chemical Characterization of Pardaxin We have purified the main proteinaceous factor (Pardaxin) from the shark-repellent secretion of the Moses sole (Pardachirus marmoratus) fish. Recently Tashibana et al. show that the Moses sole secretion in addition to bioactive proteins also possesses a group of steroid aminoglycosides (sterols). Those sterols displayed surfactant, hemolytic, toxic and shark repellent activities. They share similar activities described for Pardaxin (PX). Therefore, we were concerned whether those sterols associated with PX and are involved in some of its biological activities. We used mass spectroscopy to identify the sterols. Several sterols were identified in the Moses sole secretion, those composed of 2-5% of the protein content. However, mass fragmentation spectra (of 30 mg.) of the PX do not show the presence of such sterols.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1986
Accession Number
ADA168047

Entities

People

  • Naftali Primor
  • Philip Lazarovici

Tags

DTIC Thesaurus Topics

  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Fish
  • Mass Spectroscopy
  • Membranes
  • Molecules
  • Oceanography
  • Secretion
  • Smooth Muscle
  • Spectra
  • Spectroscopy
  • Synthetic Membranes

Readers

  • Microbial Pathology
  • Molecular and Cellular Biochemistry