Investigations Regarding Anesthesia during Hypovolemic Conditions.
Abstract
This research attends to unmet requirements in the physiological management of moderately and severely wounded soldiers, thereby a) improving the return-to-duty rate of the combat-injured, and c) reducing resource (primarily material and logistical support) utilization by Army medical field facilities. The research examines the interaction of anesthetic agents appropriate for use in a combat environment, with hemorrhage. In doing so, the physiology of hemorrhage the physiological processes that contribute to the differences among anesthetic agents for induction and maintenance of anesthesia during hemorrhage will be examined. Swine are used as the experimental model, examining rationale and physiology of use of nitrous oxide, enflurane, isoflurane, halothane, thiopent and ketamine for induction of anesthesia during the hypovolemic condition. We have characterized the awake swine response to hemorrhage, and defined the swine's blood acid-base chemistry. During hypovolemia, induction of anesthesia with either ketamine or thiopental causes similar, important deterioration of cardiovascular compensation for moderate hemorrhage. Keywords: Combat casualty management; Renin-angiotensin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 25, 1982
- Accession Number
- ADA168143
Entities
People
- Richard B. Weiskopf
Organizations
- University of California, San Francisco