Neurotoxicology of Cyclotrimethylenetrinitramine (RDX).
Abstract
This report summarizes the results of a series of experiments designed to determine in rats the behavioral effects of acute and subchronic exposure to RDX. The behavioral endpoints included measures of sensory (acoustic startle), motor (landing footspread, figure-eight maze activity) and cognitive (flavor-aversion conditioning, acquisition and performance of schedule-controlled behavior) capacity. Since the behavioral evaluations were to be carried out using newly assembled equipment in a newly constructed laboratory, several preliminary behavioral experiments were executed to insure that the equipment and test conditions were appropriate. Additional pilot experiments determined the appropriate conditions for measuring RDX levels in blood and brain, and the time course of RDX levels in blood and in brain. Phase I involved determining the acute effects of RDX. The results of these experiments showed that RDX produced a multitude of behavioral effects. Phase II involved determining the subchronic effects of RDX. Keywords: Behavioral toxicology, and motor activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1985
- Accession Number
- ADA168266
Entities
People
- L. C. Cook
- Q. D. Walker
- R. C. Macphail