Stress and Neuroendocrine Regulation of Immune Responses.
Abstract
Work is currently in progress on establishing a consistently reproducible paradigm for stress-induced immunosuppression in the mouse. Preliminary data indicate decreases in spleen and thymus weights, and in T-cell responsivity to mitogens following brief periods of restraint or electric footshock, especially with repeated treatments. Other preliminary data indicate that brain dopaminergic and noradrenergic systems respond acutely to the injection of a viral antigen (NDV), in addition to the previously reported increases in plasma corticosterone. The cerebral responses are particularly evident in hypophysectomized mice, in which we do not observe substantial increases in plasma corticosterone. We have not observed consistent changes in cerebral amines following injection of activated spleen cell supernatants, or thymosin fraction V (Tf-5). In a collaborative study, we found that Tf-5 does not directly alter corticosterone binding to its brain receptors, thus ruling out one potential mechanism for the anti-stress properties of Tf-5. Keywords: Stress, Nervous system, Immune system, Catecholamines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 20, 1986
- Accession Number
- ADA168768
Entities
People
- Adrian J. Dunn
- Nicholas R. Hall
Organizations
- University of Florida