Carbamate Induced Performance Decrement Restored with Diazepam and Atropine in Rats,
Abstract
When rats (500g, male) are exercised to exhaustion on a treadmill, pretreatment with the carbamate physostigmine reduces endurance capacity. Our objective was to determine whether pharmacological intervention could reverse these decrements in performance. The following drugs were administered separately via tail vein: vehicle-control (C), atropine (200 ug/kg, A), diazepam (500 ug/kg, D), and physostigmine (200 ug/kg, PH). After drug administration, rats were run (11 m/min, 6 deg elevation, Ta = 26 c) to exhaustion (unable to right themselves when placed on their backs). PH administration resulted in reduced endurance (41 min PH vs 53 min C, P<.05) with greater increments in core temperature (0.090 C/min PH vs 0.057 C/min C, p<.01) than control rats. However, when A and D were also given to PH treated rats, the run time and heating rate were restored to control levels. Further, A and D without PH improved performance (82 min, 0.047 C/min) over control levels. Serial administration of an anticholinergic, an anticonvulsant, and an anticholinesterase resulted in no significant change in performance from control levels. Keywords: Temperature regulation; Heat stress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1986
- Accession Number
- ADA169288
Entities
People
- Candace B. Matthew
- Glenn J. Thomas
- Ralph P. Francesconi
- Roger W. Hubbard
Organizations
- United States Army Research Institute of Environmental Medicine