Genotoxicity and Carcinogenesis: A Brief Survey
Abstract
Much of the recent research into the mechanisms and causes of cancer has dealt with the genetic aspects of carcinogens, particularly on somatic cells. Organic compounds that invade the body are usually metabolized and excreted; however, a small percentage react with DNA and other cellular macromolecules. If the damaged genome is not repaired, mutations may result that occassionally lead to malignant transformation. Because of the cost (both time as well as monetary) of testing animals, short-term assays have been developed that measure the different effects of agents on cells, therefore providing data for predicting the genotoxicity in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1986
- Accession Number
- ADA169592
Entities
People
- William E.