Pharmacological Resetting of the Circadian Sleep-Wake Cycle.

Abstract

This research program developed strategies to reset the timing of the circadian (approximately 24-hour) sleep-wake cycle so that individuals could be maintained fully awake in any predetermined time in the 24-hour day. This capability would be of direct benefit in minimizing the deleterious effects of jet-lag and could promote alertness in facilities which must be staffed 24 hours a day. The studies utilized a diurnal primate primate, the squirrel monkey (Saimiri sciureus), with a well defined circadian neurophysiology and sleep-wake physiology. This animal has a consolidated sleep-wake cycle that is comparable to that in humans. During the three-year period of funding, the circadian sleep-wake organization in squirrel monkeys was characterized, and the rate of resynchronization after phase shifts of environmental light-dark cycles was determined.

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Document Details

Document Type
Technical Report
Publication Date
May 30, 1986
Accession Number
ADA170804

Entities

People

  • Martin C. Moore-ede

Organizations

  • Harvard Medical School

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Anticonvulsants
  • Biological Sciences
  • Biophysics
  • Body Temperature
  • Brain
  • Circadian Rhythms
  • Diseases And Disorders
  • Drug Abuse
  • Jet Lag
  • Medical Personnel
  • Neurophysiology
  • Neurosciences
  • Physiology
  • Recording Systems
  • Rodents
  • Scientific Research

Readers

  • Cardiovascular Physiology
  • Circadian Sleep-Wake Regulation and Chronobiology