HMX: 14 Day Toxicity in Mice by Dietary Administration
Abstract
Male and female mice were fed diets containing up to 500 mg HMX/kg/ day for 14 days with the object of selecting dose levels for a 13 week study. Deaths occurred in males at 300 mg/kg and above and in females at 800 mg/kg and above. Clinical signs included hyperkinesia. Histopathology of premature decedents revealed some hepatocellular hyperplasia, cytoplasmic eosinophilia and cellular depletion of splenic red and white pulp. Cause of death was not determined.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 30, 1985
- Accession Number
- ADA171596
Entities
People
- P. Mcdonald
- R. J. Greenough