HMX: 14 Day Toxicity Study in Rats by Dietary Administration
Abstract
Male and female rats were dosed via the diet for 14 days with HMX in order to select dose levels for a 13 week study. Concentrations were selected to give doses of 0, 100, 1000, 3000 and 9000 mg HMX/kg/day. Deaths occurred in males at 9000 mg HMX/kg/day and in females at 1000 mg HMX/kg/day and above. There were substantial effects on food intake and upon body weight. Histopathological examination revealed centrilobular toxic degeneration in the lives of male and female rats. There was also hepatocyte hyperplasia, increased cyto plasmic eosinophilia in the liver and lymphocytic depletion in the spleen and thymus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 30, 1985
- Accession Number
- ADA171597
Entities
People
- P. Mcdonald
- R. J. Greenough