HMX: 13 Week Toxicity Study in Mice by Dietary Administration
Abstract
Mice were fed diets containing HMX for 13 weeks. Dose levels for males were 0, 5, 12, 30, 75 or 200 mg HMX/kg/day. Female mice received 0, 10, 30, 90, 250 or 750 mg HMX/kg/day. Mortalities attributable to HMX at 200 mg HMX/ kg/day amongst males and at 250 and 750 mg HMX/kg/day amongst females. Occasional deaths at lower dose levels were of uncertain aetiology. No marked effects on body weight were noted although food consumption was reduced amongst higher dosed males and females. There were slight but equivocal changes in haematological and clinical chemical observations. Neither gross autopsy nor histopathology revealed any findings likely to be associated with the administration of HMX.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1985
- Accession Number
- ADA171602
Entities
People
- D. J. Everett
- S. M. Maddock