HMX: Analysis in Plasma Obtained after 90 Day Toxicity Studies with Rats and Mice
Abstract
A sensitive method was developed for analysis of HMX in the plasma of laboratory rodents. It is based on reverse phase HPLC and has a limit of detection around 20 ng/ml. Analysis of blood samples from 13 week rat and mouse toxicity studies revealed that: Rat plasma levels were very low and did not increase with increasing dose levels. It is therefore likely that most of the material was not absorbed. Insufficient plasma was available from the 13 week mouse study for successful analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1985
- Accession Number
- ADA171603
Entities
People
- M. S. Henderson