Scintigraphy for Pulmonary Capillary Protein Leak
Abstract
Pulmonary gamma scintigraphy is a rapid, non-invasive technique for measuring a pulmonary capillary protein leak in ARDS. In these studies, the method demonstrated that the acute anesthetized lung lymph fistula sheep model was associated with a significant pulmonary capillary protein leak. No leak was demonstrated in dogs following either large doses of Intralipid, sodium morrhuate or endotoxin. The protein leak following oleic acid could not be prevented with methylprednisolone (30 mg/kg), ibuprofen (12.5 mg/kg) MK-447 (4 mg/kg), or calcium gluconate (140 mg/kg). A significant and persistent leak followed the installation of 0.1 hydrochloric acid into the trachea of dogs. Additional studies relating to these issues are in progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1982
- Accession Number
- ADA171718
Entities
People
- Alfred M. Strash
- Harvey J. Sugerman
- James L. Tatum
- Jerry I. Hirsch
Organizations
- Virginia Commonwealth University School of Medicine