Scintigraphy for Pulmonary Capillary Protein Leak
Abstract
Pulmonary gamma scintigraphy is a rapid, non-invasive technique for measuring a pulmonary capillary protein leak in ARDS. In these studies, the method demonstrated that the acute anesthetized lung lymph fistula sheep model was associated with a significant pulmonary capillary protein leak. No leak was demonstrated in dogs following either large doses of Intralipid, sodium morrhuate or endotoxin. The protein leak following oleic acid could not be prevented with methylprednisolone (30 mg/kg), ibuprofen (12.5 mg/kg), MK-447 (4 mg/kg), or calcium gluconate (140 mg/kg). A significant and persistent leak followed the instillation of 0.1 hydrochloric acid into the trachea of dogs. This was not altered with pre-treatment with 30 mg/kg methylprednisolone or 12.5 mg/kg ibuprofen. Prostacyclin (PGI sub2) infusion at 0.3 mcg/kg/min increased the rate of leak, as measured by the SI, by 50%. A significant SI was noted in pigs following the intravenous infusion of Pseudomonas (1,000,000,000 orgs/kg/ min). Studies will be undertaken to investigate the ability of various agents (methylprednisolene, ibuprofen, PGI sub2) to alter the SI following Pseudmonas infusions in the pig. Atelectasis was produced in 5 dogs by inflation of a balloon in the right main bronchus and repeat SI's were obtained. Altelectasis did not produce an increased SI. These studies will be compared to a group of dogs in which a right lobar pneumococcal pneumonia will be produced..
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1983
- Accession Number
- ADA171731
Entities
People
- Alfred M. Strash
- Harvey J. Sugerman
- James L. Tatum
- Jerry I. Hirsch
Organizations
- Virginia Commonwealth University School of Medicine