Kinetics Modeling of Cancer Immunology.
Abstract
In the presence of antibody, some cancerous antigens have demonstrated a unique mechanism of immunological escape. The mechanism by which these tumors avoid immune destruction is to constantly change their antigen surface, thus preventing the immune system from effectively completing its response to a given antigen. The exact means by which these tumor cells change their antigen surface is unknown. In this study, a kinetics model for an immune response to such a system is presented. Comparisons between the model data and experimental data indicate similar response characteristics, e.g. amplitude, shape, and oscillation frequency of the cancer cell populations, thus lending credibility to the mathematical model. In addition, parameters of the model are varied to note the degree of sensitivity of the cancerous system, in order to achieve further meaningful results. Finally, concepts for a more rigorous model, including more intercellular interactions, are proposed.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 09, 1986
- Accession Number
- ADA171737
Entities
People
- Scott W. Helmers
Organizations
- United States Naval Academy