Corticosteroid/Antibiotic Treatment of Septic Shock: An Evaluation of Mechanisms.
Abstract
We have succeeded in developing the first effective therapy to prevent death from septic shock induced by a 100% lethal dose of live E. coli organisms administered intravenously to dogs and non-human primates. The therapy consists of intermittent infusions of the corticosteroid, methylprednisolone sodium succinate, and the aminoglycoside antibiotic, gentamicin sulfate. Application of the therapy soon after initiation of E. coli administration has increased survival (>7 days) from 0% to 100% in both dogs and baboons. The purpose of this study was to delineate the exact mechanisms of protection of our corticosteroid/antibiotic therapy including how it is involved with the cardiovascular, metabolic, endocrinologic and host-defense systems of the septic animal. We have particularly emphasized evaluation of therapy interaction with adrenal cortex, lung, liver, and leukocytes. We have also assessed the significance fo beta-endorphins in the pathogenesis of shock and assayed the role of therapy interaction with adrenal ectomized, and isolated working left ventricle preparations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 29, 1984
- Accession Number
- ADA172399
Entities
People
- Lerner B. Hinshaw
Organizations
- University of Oklahoma Health Sciences Center