Organophosphates: Genetics Receptors and Antidotes.
Abstract
Inbred mouse strains were found to differ in sensitivity to a number of behavioral and physiological effects elicited by DFP as well as in lethality. These differences were not easily explained in terms of differential inhibitors of acetylcholinesterase (AChE). Nicotine-induced seizures were studied as a model system for organophosphate-induced seizures. Nicotine-induced seizures seem to be regulated, in the mouse, by a limited (perhaps one) number of genes and these genes also seem to regulate the number of hippocampal nicotinic receptors. Acute studies with DFP indicated that brain AChE activity does not return to control levels in adult male mice but control levels are regained in reaggregate brain cultures and in DFP-treated mouse pups. Similarly, QNB binding did not return to control in striatum of DFP-treated mice. This, plus the absence of tolerance development, suggests that DFP may cause irreversible damage to mouse brain.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1986
- Accession Number
- ADA173157
Entities
People
- Allan C. Collins
Organizations
- University of Colorado Boulder