Research and Development on Inhalation Toxicologic Evaluation of Red Phosphorus/Butyl Rubber Combustion Products
Abstract
Combinations of exposure concentrations, durations and frequencies were tested in four week inhalation exposures followed by two weeks of recovery to define the interactive effects of these variables on biologic responses and to select the most sensitive biologic response parameters for the subsequent subchronic studies. Response surface modeling was used for the experimental design and statistical analysis of the data. Results of preliminary testing suggested that exposure duration and frequency did not have major effects. Subsequently male and female Sprague-Dawley rats were exposed in separate studies to RP/BR aerosols ranging from 0.40 to 1.20 mg/1 or to filtered air for 2.25 hr/day on four days/week for four weeks. Test atmosphere monitoring data demonstrated that aerosol concentrations were consistently within 4% of the target values and mean particle size ranged from 0.44-0.64 micrometers with mean sigma g's of 1.66-1.97. During the exposure period, wheezing and labored breathing were observed in male rats exposed to the high dose. Decreased body weights, body weight gains and reduced food consumption seen in male rats only at all concentration levels during the exposures returned to normal after the recovery period. Various biological endpoints were examined within 1-hr after the last exposure, and for selected treatment groups after a 14-day recovery period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1984
- Accession Number
- ADA173549
Entities
People
- Catherine Aranyi
Organizations
- IIT Research Institute