Immunomodulation by Proteins of Bordetella pertussis

Abstract

Endotoxin associated proteins (EP) from Bordetella pertussis and Salmonella typhi have been found to be potent immunomodulators. EP is an adjuvant for T-dependent and T-independent antigens. Both the primary and secondary antibody responses to T-dependent antigens are enhanced. T-cells and macrophages act as accessory cells in this adjuvant effects; however, a significant portion of the enhanced antibody response to any one antigen is due to polyclonal activation by EP. In addition EP activates macrophages to produce the lymphokine Interleukin-1 which may play a role in the adjuvant effect as well. Finally, lipopolysaccharide endotoxin derived from Bordetella pertussis has been found to activate the B-cells and macrophages of C3H/HeJ mice which are hyporesponsive to LPS endotoxin from enteric Gram-negative bacteria.

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Document Details

Document Type
Technical Report
Publication Date
Oct 31, 1986
Accession Number
ADA174477

Entities

People

  • Barnet M. Sultzer
  • John P. Craig

Organizations

  • State University of New York

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkanes
  • Antigens
  • Biological Factors
  • Blood
  • Blood Cells
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Endotoxins
  • Gram-Negative Bacteria
  • Immunization
  • Immunomodulation
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Proteins
  • Vaccines

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Microbial Pathology