Choline Uptake by Glomerular Synapses Isolated from Bovine Cerebellar Vermis.
Abstract
Tritium Choline uptake was investigated in a highly enriched preparation of glomerular particles isolated from bovie cerebellar vermis. Kinetic analysis indicates that a high affinity uptake sytstem with a relatively low maximum uptake velocity is present. At a substrate concentration of .0000001 M, Tritium choline uptake was shown to be sodium-dependent, hemicholinium-sensitive and nonreactive to increasing concentrations of unlabeled choline. These findings support the presence of a high affinity choline uptake system in cerebellar glomeruli and would seem to be consistent with the suggestion that a small proportion of mossy fibers are cholinergic in this brain region.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1986
- Accession Number
- ADA174605
Entities
People
- D. M. Terrian
- E. L. Noisin
- W. E. Thomas
Organizations
- United States Air Force School of Aerospace Medicine