Cloning of the poly(ADP-ribose) Gene from Rat Liver.

Abstract

Inhibition of the nuclear enzyme poly (ADP-ribose) polymerase by substances that interfere with the DNA binding of the enzyme molecule profoundly inhibit cellular phenotypic changes (malignant transformation) induced either by non-toxic doses of ultimate carcinogens and more recently in an oncogene construct-containing cell line by steroid hormones. Enzyme inhibition in ontogenically stable cells had no measurable physiological effect as tested by cell growth or viability, thus the biological role of poly (ADP-ribose) polymerase seems to be confined to cells undergoing differentiation, development or oncogenesis that occurs without detectable cellular toxicity (no DNA damage).

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Document Details

Document Type
Technical Report
Publication Date
Sep 24, 1986
Accession Number
ADA174667

Entities

People

  • Ernest Kun

Organizations

  • University of California, San Francisco

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Albumins
  • Alcohols
  • Alkenes
  • Amino Acids
  • Cells
  • Cellulose
  • Chromatography
  • Classification
  • Ethylene Glycol
  • Ethylenes
  • Filter Paper
  • Filters
  • Genetic Structures
  • Molecules
  • Peptides
  • Precipitation
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology
  • Virology (or Medical Virology).