Metal Complexes for Defense against Cyanide Intoxication

Abstract

Metal complexes having high affinities for cyanide binding can be used as antidotes for cyanide intoxication. A number of water-soluble phthalocyanine complexes have been synthesized and tested for this purpose Compounds tested contain a variety of metal ions (Co(3+), Co(2+), Fe(2+), Ni(2+) , FE(3+), Cu(2+), Ru(3+), Pd(2+), Mn(4+), and V(4+) and functional groups (SO3(- ), NH3(+) and CO2(-). The rate of cyanide binding to these complexes was studied by spectroscopic methods and by the use of an ion-selective electrode. The rate of cyanide binding depends on the metal and its oxidation state. The rate constant of cobalt (II) tetracarboxyphtalocyanine is 3,400/M/s, which is about twenty times the reported rate of binding of cyanide to silated cytochrome oxidase.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1986
Accession Number
ADA174680

Entities

People

  • Robert B. Wilson Jr.
  • Yee W. Chan

Organizations

  • SRI International

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Anhydrides
  • Aqueous Solutions
  • Biomedical Research
  • Carbon Monoxide
  • Chemical Reactions
  • Coordination Complexes
  • Dielectric Gases
  • Electrons
  • Equations
  • Ion Selective Electrodes
  • Magnetic Moments
  • Measurement
  • Sodium Compounds
  • Sodium Hydroxide
  • United States
  • Visible Spectra

Fields of Study

  • Chemistry

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Electrochemical Engineering/ Fuel Cell Technologies
  • Materials Science and Engineering.