Determination of the Chronic Mammalian Toxicological Effects of RDX. Acute Dermal Toxicity Test of Hexehydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) in Rabbits
Abstract
This study was conducted to evaluate the dermal toxicity of the munitions compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX; CAS Reg. No. 121-82-4) in New Zealand Albino rabbits after a single application of 2 g/kg in carboxymethylcellulose (1%). Toxicological endpoints included body weight measurements, observations of clinical signs and mortality. Although two males died during the 14 day observation period, gross necropsy and microscopic examination found Tyzzer's Disease as the cause of death. A slight, transient body weight loss was evident for most of the surviving animals, and no other signs of toxicity were observed. To ensure the integrity of the results, the study was repeated only on male rabbits of the same strain but from a different supplier. This repeat study resulted in no mortality. The results of acute dermal toxicity of RDX, 2 g/kg in carboxymethylcellulose on single application to rabbit skin show a slight transient body weight loss, no clinical signs of toxicity, and found no mortality in male and female rabbits up to a 14-day observation period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1984
- Accession Number
- ADA174710
Entities
People
- Barry S. Levine
- E. M. Furedi-machacek
- Paul M. Lish
Organizations
- IIT Research Institute