A Study of the Toxicity of the Metabolites of the Cruise Missile Fuel JP-10 on Several Animal Species.

Abstract

Groups of male and female Fischer 344 rats, C-57-BL mice and Syrian Golden hamsters were dosed with 5-hydroxy-JP-10 and 5-keto-JP-10, the metabolites of the cruise missile fuel JP-10, in order to study their toxicity. 5-Hydroxy-JP-10 proved to be an extremely toxic central nervous system depressant. The effects of 5-hydroxy-JP-10 on weight gain appeared to be most pronounced in the male rat. 5-Keto-JP-10, because it is absorbed less readily than 5-Hydroxy-JP-10, appeared to be relatively non-toxic. Neither of the JP-10 metabolites produced nephrotoxic effects in the doses administered.

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Document Details

Document Type
Technical Report
Publication Date
Sep 30, 1986
Accession Number
ADA174750

Entities

People

  • M. P. Serve'

Organizations

  • Wright State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Body Weight
  • Central Nervous System
  • Chlorides
  • Classification
  • Cruise Missiles
  • Cyclic Hydrocarbons
  • Fuels
  • Gas Chromatography
  • Glucuronic Acids
  • Hydrocarbon Fuels
  • Hydrocarbons
  • Mass Spectrometers
  • Mass Spectrometry
  • Metabolism
  • Security
  • Toxicity

Readers

  • Petroleum Engineering
  • Toxicology/Environmental Toxicology