Chemical Preparation Laboratory IND Candidate Compounds.
Abstract
Six compounds were synthesized during the reporting period: 3-Beta-D-ribofuranoxyl-1(H)pyrazolo(4,3)-Dpyrimidin-7(6H)thione (Thioformycin-B); 9-Beta-D-ribofuranoxyl-purine-6-thiocarboxamide; 3-bromo-4-chloro-pyrazolo (3.4-d)pyrimidine; 2-Beta-D-ribofuranosylselenazo-4-caboxamide; cis, trans 3,6-diethoxy-tetrazadiphosphorine-3,6-disulfide; 1-Beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Ribavirin). The syntheses of ten target compounds have been examined during this annual period. The preparations of six of the ten target compounds were completed, and the compounds were transferred to USAMRIID, Department of Antiviral Studies. The syntheses of the four remaining target compounds, three of which are unreported in the chemical literature, are being further investigated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 21, 1986
- Accession Number
- ADA174888
Entities
People
- Ernst M. Schubert