Reduced Hemorrhage Tolerance in Hyperthermic Conscious Pigs.
Abstract
We evaluated the cardiovascular response to hemorrhage (38.5 ml/kg over 60 min) in conscious normothermic (n=8) and hyperthermic (40.4 + or - 0.4 C, mean SEM; n=5) Duroc Swine (18-25 kg); hyperthermia was defined as a rectal temperature exceeding the normal range, (39.7 + or - 1 C; n=35). Animals were surgically prepared with a carotid artery catheter splenectomized seven days prior to experiments. Measurements were made at 0, 10, 20, 30, 45, and 60, minutes during hemorrhage and at 15, 30, 60, 120, 180, an 240 minutes after hemorrhage. All eight of the normothermic pigs survived. One of the animals with an elevated temperature died in the course of the hemorrhage and two after hemorrhage (P<0.035). Before hemorrhage, animals with elevated body temperature had significantly (P<0.05) increased mean arterial pressures 119 + or - 3 vs 99 + or - 3 mmHg) and heart rates (143 + or - 7 vs 112 + or - 5 b/m) compared to animals with normal body temperatures. At the end of hemorrhage there was no difference in mean arterial pressures (48 + or - 11 mmHg, N=4) for hyperthermic pigs and (48 + or - 2 mmHg, n=8) for normals. Heart rates at the end of hemorrhage were greater in the hyperthermic (183 + or - 26 b/m) than in the normothermic pigs (146 + or - 8 b/m). Pigs with elevated body temperature, presumably due to some low grade infection at the catheter exit site, had a reduced tolerance to hemorrhage. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1986
- Accession Number
- ADA175248
Entities
People
- Berry F. Williams
- Carol A. Bossone
- Charles E Wade
- John P. Hannon
Organizations
- Letterman Army Hospital