Interaction of Phenyldichloroarsine with Biological Molecules

Abstract

Carbon 14 -Phenyldichloroarsine (PDA) was used to study the binding of PDA to erythrocytes and stroma-free hemoglobin. Natural abundance Carbon 13- nuclear magnetic resonance spectroscopy (Carbon 13-NMR) was used to study the binding of DPA to glutathione, meso-2,3-dimercaptossuccinic acid (DMSA), and British anti-Lewisite (BAL). The results clearly show that PDA penetrates the red cell and is contained within. Apparently hemoglobin is not the internal sulfhydryl-containing species that holds the DPA, glutathione appears to be a better candidate. Carbon 13-NMR is a promising tool for investigating DPA complexes.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1986
Accession Number
ADA175296

Entities

People

  • Evelyn L. Mcgown
  • Kilian Dill
  • Richard J. O'connor

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Arsenicals
  • Biological Sciences
  • Blood
  • Blood Cells
  • Cells
  • Chemical Shifts
  • Chemical Synthesis
  • Chemistry
  • Engineering
  • Magnetic Resonance
  • Materials
  • Materials Science
  • Molecules
  • Nuclear Magnetic Resonance
  • Resonance
  • Spectra

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Cardiovascular Physiology