Dihydropyridine Receotprs: Possible Allosteric Regulation by Tremorgenic Toxins.

Abstract

Dihydropyridine (DHP) receptors appear to be coupled to voltage-sensitive calcium channels that mediate Ca(++) flux in neural tissue. A number of toxins known to interact with these channels induce tremors and seizures and modulate the ability of DHP compounds to alter the gating properties of Ca(++) channels. It is therefore likely that tremorgenic myco-toxins, an economically important group of fungal toxins, may modulate Ca(++) channels either directly or by their ability to act at DHP receptors. Tremorgenic doses of aflatrem, cyclopiazonic acid, and verruculogen increase the number and decrease the affinity of DHP receptors in rat cortex. These results suggest that the Ca(++) channel and its associated receptors are important targets for several classes of fungal toxins.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1986
Accession Number
ADA175458

Entities

People

  • David H. Ross
  • James J. Valdes
  • Vicki L. Wolff

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Biological Toxins
  • Cells
  • Classification
  • Data Analysis
  • Fungi
  • Identification
  • Laboratory Animals
  • Mycotoxins
  • New England
  • Pharmacology
  • Regulations
  • Security
  • Technical Information Centers
  • Tissues
  • Toxins

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience
  • Small Business Innovation Research Program (SBIR) EDI Research and Innovation.