An Investigation of the Causes of the Blood Platelet Storage Lesion
Abstract
Evidence of the generation of thrombin in the preparation and storage of standard, citrated platelet concentrates has been found. A support mechanism in platelet concentrates for thrombin generation; namely, platelet activation and expression of procoagulant activity by stored platelets has been identified. These results were obtained through an examination of the levels of fibrinopeptide-A and platelet factor 3 in platelet concentrates prepared by standard techniques. It has been shown in preliminary experiments that addition of agents that inhibit thrombin activity and inhibit platelet activation results in markedly improved platelet storage at least by in vitro markers. Follow-up studies are in progress. Keywords: human blood donors; Blood storage; Blood coagulation; Blood agents; Hematology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 29, 1985
- Accession Number
- ADA176751
Entities
People
- Arthur P. Bode
- David T. Miller