The Effects of Oral Pyridostigmine on Serum Cholinesterase Activity in Macaca mulatta
Abstract
Pyridostigmine bromide was administered orally to groups ( n = 6) of Rhesus monkeys at doses of 0.0 (vehicle only), 0.5, 1.0, 2.0, and 4.0 mg/kg. Serum cholinesterase activity was assayed for blood samples drawn 1,2,4,8, and 16 h after pyridostigmine ingestion. The largest inhibition of cholinesterase activity was observed at 2 h after ingestion. A dose of 2.0 mg/kg produced 40.9 + or - 6.8% inhibition. At the highest dose, excessive salivation was observed during ingestion, suggesting a dose-related artifact in the amount of drug actually consumed. Adequate experimental control of pyridostigmine dose would require administration either by intubation or by ejection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1987
- Accession Number
- ADA176789
Entities
People
- Dennis W. Blick
- Duane P. Dawson
- G. C. Brown
- Michael R. Murphy