Nonspecific Resistance Induced by an Immunopharmacologic Agent Derived from Bordetella pertussis

Abstract

Treatment of mice with a trichloroacetic acid soluble extract of Bordetella pertussis (Boivin antigen) induces resistance to a lethal dose challenge of mouse adenorius. The resistance develops within 2-3 days after treatment and persists for 10 days and possibly longer. The TCA-soluble extract designated EP-LPS (Endotoxin associated proteins and lipopolysaccharide) consists of proteins that may or may not be complexed to the lipopolysaccharide under nondenaturing conditions. Although EP-LPS induced a notable increase of lymphocytes in the blood and peritonenum and a marked decrease of monocytes and macrophages in the peritoneum, investigation of B cell, T cell, NK cell, and macrophage activities failed to demonstrate ayn striking mechanism that might account for antiviral activity. In a search for an adjuvant to replace alum we discovered that block copolymers L121 and T150R1 in combination exhibited antiviral activity. Keywords: Boivin antigen immunomodulation.

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Document Details

Document Type
Technical Report
Publication Date
Feb 02, 1987
Accession Number
ADA176946

Entities

People

  • Alvin L. Winters
  • Gary L. Sloan
  • Paul A. Leblanc

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Bacterial Infections
  • Biological Factors
  • Biological Sciences
  • Biological Toxins
  • Biomedical And Dental Materials
  • Blood
  • Cardiovascular System
  • Cells
  • Chemistry
  • Immunomodulation
  • Leukocytes
  • Lymphocytes
  • Microbiology
  • Military Research
  • Vaccines
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Materials Science.
  • Molecular and Cellular Biochemistry

Technology Areas

  • Microelectronics