Intraerythrocytic Killing of Malaria Parasites
Abstract
The purpose of these studies is to determine the role of activated macrophages in immunity to the blood stages of malaria. This is being accomplished by comparing the activity of macrophages during lethal and non- lethal malaria infections and in malaria-resistant and non-resistant mice. We have found that peritoneal macrophages from both outbred and inbred mice infected with the non-lethal strains of Plasmodium yoelii produce higher levels of hydrogen peroxide than do mice infected with the lethal strain of the same parasite. In addition, spleen cells from mice infected with non-lethal P. yoelii have higher antibody dependent cellular cytotoxicity levels than those from a lethal infection. Further studies will determine the hydrogen peroxide response of spleen cells in these models, the nature of the lymphokines produced, and the ability of immune sera from each infection to enhance cytotoxicity. Keywords: Cytotoxins; Parasitic diseases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1986
- Accession Number
- ADA177182
Entities
People
- Hannah L. Shear