The Mechanism of Blood Function and Production After Injury.
Abstract
These studies include comparison of essential and nonessential amino acids and total parenteral nutrition, a clinical study in which the causes of sepsis were identified and institution of precautions led to a drop in sepsis in the site hospital. Various animal experiments have studied the effects of nutrition on anemia secondary to burn trauma finding that changes in levels of 2,3 DPG modify this change. Similar studies evaluating the immune system in an animal model of trauma have dissected some of the abnormalities found in the traumatized animal suggesting that protein depletion reduced antibody forming cells. A septic model in animals, the hemoglobin E. coli peritonitis model was used to evaluate the effect of nutrition on outcome and one of the clinically applicable findings was the difference in survival between animals receiving total parenteral nutrition via the intravenous route and those receiving oral nutrition showing that those animals receiving the oral feedings had statistically significant increased survival rate. Preliminary data suggests that complex methods of providing intravenous nutrition may have a more limited role than was previously felt and that oral nutrition in all injured patients should be pressed more than it is at present.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADA177282
Entities
People
- George F. Sheldon
Organizations
- University of California, San Francisco