Rare 2-Substituted Purine Nucleosides.
Abstract
This project is concerned with the synthesis of rare 2-substituted purine nucleosides with therapeutic potential against RNA viruses. The goals were to develop rational procedures for the synthesis of the target molecules discussed in the proposal. Synthetic procedures to eight of the target molecules were developed. Two of these compounds, both inosine analogues, were submitted for antiviral evaluation. Four others were in various stages of preparation for submission. In the course of this research investigation conceptually new synthetic methodologies in purine nucleoside chemistry were also discovered.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1986
- Accession Number
- ADA177303
Entities
People
- Vasu Nair
Organizations
- University of Iowa