Mechanisms of Cellular Membrane Effects of TCDD (2,3,7,8-Tetrachlorodibenzo-p-Dioxin) Selected Perfluorinated Acids and Polyhalogenated Aromatic Hydrocarbons.

Abstract

Two model systems were used to examine the phenomenon of metabolic cooperation between cells. The recovery of ARL-TG superscript r cells in the presence of hepatocytes and 6-thioguanine was examined. Perfluorodecanoic acid and 2, 2' 4, 4' 5, 5' hexachlorobiphenyl have significant effects on metabolic cooperation between cells; implying that these chemical interfere with gap junction function and hence interrupt cell-cell communication. These results were confirmed in autoradiographic studies in which the transfer of Tritium uridine between donor and recipient cells was examined. If these compounds inhibit cell-cell communication in vivo, then that may be one mechanism by which the toxic effect is exerted. Keywords: Polychlorinated biphenyls.

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Document Details

Document Type
Technical Report
Publication Date
Oct 15, 1986
Accession Number
ADA177372

Entities

People

  • Rogers-beck

Tags

DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Biphenyl
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Contracts
  • Culture Techniques
  • Cyclic Hydrocarbons
  • Epithelial Cells
  • Fatty Acids
  • Hydrocarbons
  • Intercellular Junctions
  • Octanoic Acid
  • Toxicity

Readers

  • Breast cancer cell signaling and growth regulation.
  • Organic Chemistry
  • Toxicology/Environmental Toxicology