Pharmacological Sparing of Protein and Glucose in Burn Injury and/or Sepsis.
Abstract
Investigated were the roles of insulin and glucagon as mediators of changes in glucose and alaine kinetics during the hypermetabolic response to injury in burn patients and in dogs. In this report, the results of experiments in 10 burn patients are presented. Those patients were infused with somatostatin, with and without insulin replacement. Glucose and alanine kinetics were measured by primed-constant infusions of glucose and alanine. The basal rate of glucose production and alanine flux were significantly elevated in all patients. Lowering both hormones simultaneously caused an insignificant reduction in glucose production, but plasma glucose rose significantly. Alanine flux and total plasma amino nitrogen increased significiantly above basal. Selectively lowering glucagon concentration decreased glucose production and exogenous glucose was infused to maintain euglycemia. Alanine flux and total plasma amino nitrogen remained unchanged. In severely burned patients hyperglucagonemia stimulates increased glucose production, basal insulin suppression glucose production, stimulates basal glucose clearance, and is important for regulation of plasma amino acid concentrations, and the selective lowering of glucagon while maintaining basal insulin constant normalized glucose kinetics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1986
- Accession Number
- ADA177378
Entities
People
- Robert R Wolfe
Organizations
- University of Texas Medical Branch