Potential Vaccine for Anthrax.
Abstract
Discussed is the development of a procedure to purify spores of Bacillus anthracis and other bacilli. A polysaccharide was purified from cell walls of B. anthracis. It is expected that the polysaccharide will prove to be a good immunogen, and may in fact be useful as vaccine. Procedures were developed for the detection of the polysaccharide, based on enzyme-linked lectinosorbent assays. A surface array protein was observed on strains of B.anthracis. The surface array could be solubilized by detergents, a finding which could lead to its purification and characterization. Further studies should be conducted concerning the characterization of the Polysaccharide and the surface array. These two molecules may provide a means to developing an effective vaccine for anthrax.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 30, 1986
- Accession Number
- ADA177440
Entities
People
- Ronald J. Doyle
Organizations
- University of Louisville