New Disinfection Agents for Water.
Abstract
Further comparisons of 3-chloro-4,4-dimethyl-2-oxazolidinone (Compound I) with calcium hypochlorite (HTH) as field water disinfectants have been made. A mixture of 10 parts Compound I and 1 part HTH at low total chlorine concentration (1 mg/L) was able to kill S. aureus in demand-free water rapidly at time zero due to the small amount of HTH present and then with Compound I disinfection kinetics upon several rechallenges over a 1-month period. Compound I was considerably more stable than was HTH in demand-free water under tropical conditions (37C) except in highly alkaline water(pH 9.5). Seven N-halamine disinfectants were synthesized during the past contract year. Most of these compounds were more bactericidal than Compound I; one of the compounds was more stable in water than Compound I. The efficacies of Compound I and HTH against rotavirus were compared under a variety of conditions with HTH being the better disinfectant. In similar experiments involving Entamoeba invadens and Giardia Lamblia Compound I was more effective than HTH in water disinfection. Mechanistic studies showed that Compound I attacks sulfhydryl groups on enzymes more rapidly than does HTH; on the other hand, aromatic amino acids react more efficiently with HTH than they do with Compound I. The mechanisms of action of the two compounds are clearly different and dependent upon the nature of the organism. Keywords: Water disinfections; N-Chloramines; HTH; Bacteria; Viruses; Protozoa; Giardia lamblia; Stability in water; 3-Chloro-4,4-dimethy1-2-oxazolidinone; Calcium hypochlorite.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1985
- Accession Number
- ADA177547
Entities
People
- Dana Williams
- H. H. Kohl
- J. L. Aull
- L. J. Swango
- S. D. Worley
Organizations
- Auburn University