Modulating Transfer RNA Anticodon Modifications and Biologic Responses in Human Cells.

Abstract

Regional and cellular specialization for the effects of tricyclic antidepressants (TAD) on sensitivity to activation by guanyl nucleotides when cerbellar tissue was compared with cortex and hypothalamus. Cerebellar synaptosomes did not show the increased sensitivity exhibited by the other brain regions. An adenosine analog N6, R-phenyl isopropyl adenonine (PIA) was used to examine the effect of adenosine on synaptosomal adenylate cyclase prepared from both TAD treated and control animals. PIA is far more effective as a cylase inhibitor in TAD treated animals than controls. Keywords: GTP (Guanosine triphosphate).

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1985
Accession Number
ADA177580

Entities

People

  • John S. George
  • Mark W. Bitensky

Organizations

  • Los Alamos National Laboratory

Tags

DTIC Thesaurus Topics

  • Adenosine
  • Antidepressants
  • Brain
  • Cells
  • Chemical Compounds
  • Genetic Code
  • Guanosine
  • Hypothalamus
  • Inhibitors
  • Nucleotides
  • Ribonucleic Acids
  • Sensitivity
  • Specialization
  • Synaptosomes
  • Trna

Fields of Study

  • Biology

Readers

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