An in Vitro Study of N,N-Diethyl-M-Toluamide (DEET) as a Neurotoxin.
Abstract
This thesis is an vitro analysis of N,N-diethyl-m-toluamide (DEET), and was accomplished by evaluating nerve conduction velocity and relatively refractory period of the rat sciatic nerve. Experimental animals about six months old were dosed with technical grade DEET for 28 days at 1.6, 1.4, 1.2, 1.0, 0.8, and 0.6 g/kg/day. All animals in the high dose group died within a few days after the start of the experiment. Nearly half of the 1.4 g/kg/day group died before experiment termination, and at least one animal from each of the other dose levels died. The results of the experiment indicated there was no significant change in nerve conduction velocity compared to the control animals. The relative refractory period of the DEET animals was statistically different from the control animals and indicated a reduction in neuroexcitability. Keywords: Insecticides; Pesticides.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1986
- Accession Number
- ADA177658
Entities
People
- Kerry R. Campbell
Organizations
- Air Force Institute of Technology