Antimalarial Cyclic Peroxide Lactones.
Abstract
Attempted synthesis of qinghaosu by methods shown in schemes 4-7 was carried out. Compound 16 (scheme 4) was synthesized in good yield. However, it failed to yield 18 by alkylation with 17 and LDA. By use Zhou's method, we have synthesized Zhou's compound 4 (scheme 3). Alkylation of 4 with trimethylsilyl vinyl methyl ketone is currently in progress. Keywords: Antimalarial Agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 29, 1986
- Accession Number
- ADA177858
Entities
People
- Kuo-hsiung Lee
Organizations
- University of North Carolina at Chapel Hill