Studies to Control Endemic Typhoid Fever in Chile

Abstract

A multi-faceted program of applied research has been undertaken to lead to control of endemic typhoid fever in Santiago, Chile. These studies include: 1) Maintenance of prospective epidemiologic and bacteriologic surveillance in three large-scale field trials evaluating the efficacy of Ty21a live oral typhoid vaccine given in various formulations and immunization schedules. 2) The first evaluations of Ty21a vaccine in infants and pre-school children. 3) Development of a new enzyme-linked immunosorbent assay (ELISA)to measure Vi antibodies and its use as a serologic screening test to identify chronic typhoid carriers. 4) Evaluation of a new oral antibiotic regimen to eradicate the chronic typhoid carrier state without resort to surgery.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1986
Accession Number
ADA177994

Entities

People

  • Catterine Ferreccio
  • Myron M. Levine

Organizations

  • University of Maryland, Baltimore

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Bacterial Infections
  • Blood
  • Diseases And Disorders
  • Gram-Negative Bacterial Infections
  • Health Services
  • Infection
  • Maryland
  • Medical Personnel
  • North America
  • Oral Vaccines
  • Public Health
  • Side Effects
  • Therapy
  • United States
  • Vaccination
  • Vaccines

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Instructional Design and Training Evaluation.

Technology Areas

  • Biotechnology