Chronic Mammalian Toxicological Effects of LAP (Load, Assemble, and Pack).
Abstract
Confirmatory LD50 and 14-day range-finding studies on load, assemble, and pack (LAP) were conducted using the Fischer 344 strain rat in place of the Sprague-Dawley strain rat used in earlier studies. From the results of these studies, dose levels for the chronic phase of the program were established. The overall objective of the chronic phase is to provide a comprehensive definition of the long-term toxicological reactions with respect to possible lesions at the biochemical and cellular levels. Data from the acute oral studies showed the LD50 of LAP to be 300 mg/kg for male Fischer 344 rats and approximately 280 mg/kg for female Fischer 344 rats. Range-finding results indicated that levels below 0.3% in the diet would be suitable for chronic administration. Through the first 28 weeks of the chronic study, 43 of 70 male rats in the high-dose LAP group have died. Severe convulsions have been observed in high-dose males and females and in mid-dose males. Females in the high-dose have become aggressive (fighting).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1980
- Accession Number
- ADA178029
Entities
People
- Ronald J. Spanggord
- Ted A. Jorgenson
Organizations
- SRI International