Sequential Morphologic Alterations in the Foveola and Cornea of Nonhuman Subjects after Exposure to Coherent Light.
Abstract
This is an investigation of the sequential (one hour, one day, one week, one month) clinical and morphologic (light and electron microscopic) effects upon the foveolar and parafoveolar retina of single short duration pulses of coherent light at 694.3 nm and 532 nm at total intraocular energy levels of approximately three times ed50. focal injury to the retina and subjacent choroid is found to be less marked at 532 nm than at 694.3 nm. The lesions are sharply circumscribed and primarily involve the outer layers of the retina and the retinal pigment epithelium. Lesser damage occurs in the inner retina and in the choroid. Morphologic evidence of healing is noted within one hour, and progresses almost to completion within one month. The process involves a combination of phagocytosis, cellular migration and possibly cellular proliferation. Inflammatory cell infiltration and scarring is not observed. Keywords: Q-switches ruby laser; Frequency doubled neodymium laser; Foveolar retinal lesions; Sequential clinical & histopathological observations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1985
- Accession Number
- ADA178054
Entities
People
- William H. Spencer