Hemoglobin Solution Effects on the Heart: Review of 19 Research Reports.
Abstract
This paper reviews 19 articles, obtained by search of the medline file of MEDLARS database, concerning the effect of hemoglobin solutions on the myocardium. Myocardial function can be supported in the presence of stroma-free hemoglobin solution with some beneficial and some detrimental effects. Most researchers have noted decreased cardiac work, decreased aortic and left ventricular filling pressure, decreased mean left atrial pressure, improved cardiac index and increased stroke work without a change in myocardial oxygen consumption. Most authors reported that coronary vascular resistance (CVR) decreased and coronary blood flow (CBF) increased, although three papers noted the opposite. Biro noted a decreased coronary sinus pO2, implying an inadequate oxygen supply. In two papers, the researchers reported a decrease in myocardial infarct size as a result of SFHS (Stroma-Free Hemoglobin Solution) infusion possibly as a result of the decreased CVR and increased CBF. This in itself has the potential for widespread use of SFHS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1986
- Accession Number
- ADA178135
Entities
People
- D. H. Marks
Organizations
- Letterman Army Hospital