Alternative Methods for Measuring Vesicant Agent Action on Rabbit Skin
Abstract
Tissue damage to the skin of rabbits exposed to the vapors of butyl 2-chloroethyl sulfide was assessed by conventional means, by measuring the changes in water content of tissue, accumulation of Iodine 125-labelled albumin, and by changes in the signal from a laser Doppler instrument. The content of water and Iodine 125-labelled albumin in tissue significantly increases after exposure. Extravasation of red cells, as measured by a Chromium 51-labelling technique, appears to be low, indicating that, under the conditions of the experiment, damage to the capillaries appears to be not very important. Keywords: Mustard gas analog; Edema; Erythema; Chemical warfare injuries; Chemical warfare agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1987
- Accession Number
- ADA178229
Entities
People
- Carol A. Bossone
- George J. Klain
- John P. Hannon
- June R. Jaeger
- Peter J. Schmid
Organizations
- Letterman Army Hospital