Impermeant Solutes and Cellular Calcium Metabolism in Pathogenesis of Acute Renal Failure.
Abstract
This research into the pathogenesis of acute renal failure identified that warm ischemia is followed by a very low glomerular filtration rate, due initially to vasoconstriction (low glomerular pressure) and later to tubular obstruction. Impermeant solutes such as mannitol and polyethylene glycol improve renal hemodynamics, reduce cell swelling (which attends ischemia), and wash out tubular debris thereby reducing tubular obstruction. Verapamil and nifedipine will, on the other hand, accomplish similar effects: reducing vascular and golmerular abnormalities by minimizing calcium influx induced vasoconstriction and reducing the degree of calcium induced cell death. Glomerular filtration is improved markedly after ischemia by either of these maneuvers. Keywords: Dogs/rats mitochondria; ATP; Norepinephrine; Calcium; Verapamil; Nifedipine; Mannitol; Kidney diseases; Kidney failure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1986
- Accession Number
- ADA178272
Entities
People
- Robert W. Schrier
Organizations
- University of Colorado Boulder