Pathogenesis and Prevention of Acute Renal Failure.

Abstract

Freshly isolated rat proximal tubules and cultured rabbit tubules exposed to anoxia (100% N2) die during reoxygenation unless pH is lowered or verapamil, nifedipine, trifluoropirazine of W-7 are administered. Thus, cell death and injury from increased calcium influx or calcium-calmodulin interactions are prevented. In addition, we have determined that various methods of lowering tissue ATP does not appear to compromise the baseline or subsequent recovery of cellular function after ischemia. Using NMR technology we have also followed renal tissue metabolism during and after hypotensive shock. The efficacy of various treatment protocols in shock will be evaluated in the coming year. Acute renal failure, Rabbits/rats, Calcium Fluxes, Adenine necleotides, Tissue calcium, Morphology, Lactate dehydrogenase, Atriopeptin III, Phosphate, Calcium.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1986
Accession Number
ADA178397

Entities

People

  • Robert W. Schrier

Organizations

  • University of Colorado Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Arteries
  • Biomedical Research
  • Blood
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Colorado
  • Contracts
  • Ischemia
  • Laboratory Animals
  • Maneuvers
  • Membranes
  • Recovery
  • Sugar Phosphates
  • Technical Information Centers
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • Cellular and Molecular Pathways of Apoptosis.