A Protein Coated Piezoelectric Crystal Detector

Abstract

A research study was to be conducted to develop a piezoelectric crystal monitor for chemical agents using immobilized enzymes (cholinesterases) and an organophosphorus antibody as coatings. A monitor was to be designed that is small, simple to use, of low cost, and based on analytical methodology of suitable accuracy and sensitivity. The initial evaluation in Phase 1 was to performed using an organophosphorus chemical warfare simulant (diisopropyl methyl phosphonate) to ascertain the feasibility of the concept for military applications. The monitors were to be evaluated as to sensitivity, selectivity, response time, linear range, reproducibility, and lifetime. Keywords include: Protein coatings; Crystals, Organophosphorus compounds, Piezoelectric quartz; Enzymes; and Antibody.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1987
Accession Number
ADA179002

Entities

People

  • George G. Guilbault
  • Glenn Lubrano
  • J. Jordan
  • J. Ngeh
  • P. Foley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Accuracy
  • Albumins
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Classification
  • Crystal Detectors
  • Detectors
  • Dielectric Gases
  • Engineering
  • Flow Rate
  • Humidity
  • Measurement
  • Organophosphorus Compounds
  • Pesticides
  • Piezoelectric Crystals
  • Sodium Compounds

Readers

  • Molecular and Cellular Biochemistry
  • Neurotoxicology
  • Optical Fiber Sensing and Electromagnetic Propagation.